After the International Meeting held
in Buenos Aires, Argentina on September 24-26,1992-2007, the Faculty
Members, based on recent research on hCG extragonadal actions aside from
those related to obesity, created:
Society for Alternative Uses of human Choriogonadotropin (ISAUC)
which supersedes and widens the original
scope of the International Foundation for hCG (human
Choriogonadotropin) and Obesity Research (IFCOR)
A Not-for-profit Organization
and diffusion on the clinical effectiveness of hCG (human
Choriogonadotropin) for obesity treatment
For many years the hCG
program for weight loss enjoyed worldwide popularity
due to the excellent obtained results . Daily administration of 125 IU
of hCG plus a Very Low Calorie Diet (VLCD) Diet rapidly decreased body weight without any side effects.
patients benefited from this safe and effective weight reduction program.
Unfortunately, based on a series of double-blind studies, the United
States Federal Drug Administration (FDA) concluded in 1974 that the method was ineffective
as a treatment for obesity, and forced pharmaceutical firms to include in
their hCG information leaflets that " hCG has no known effect on fat
mobilization, appetite or sense of hunger, or body fat distribution."
Despite this conclusive statement, many patients who had been managed
with hCG in the past requested their clinicians to resume treatment with
this method. Many healthcare professionals refused, their main argument
being that: "hCG causes, among other side-effects, cancer, hirsutism
and water retention ".
However, this assertion about hCG was NOT substantiated by ANY report
in the literature. To all appearances, the method fell into disuse. In
reality, some physicians all over the world continued to manage their
patients with the hCG protocol, obtaining the same results as 47 years
Obesity has now reached worldwide proportions, and society faces a
problem that will cause more suffering, disease and death than any other
plague over the last three hundred years. The hCG method may well be a
safe and effective alternative for treating those millions of individuals
Very few healthcare professionals are eager to listen to those patients
who were formerly treated with hCG. Many obese individuals are looking for
assistance, and they get none.
The objective of the hCG and Obesity Research Fund is to create a
climate of opinion aimed at bringing hCG back into the serious attention
of scientists and the public.
You can join us by selecting from several options (see below). If you
are interested, send us your suggestions and comments to improve our task.
The hCG program for obesity treatment was published for the first time
in Letters to the Editor, in The Lancet, a reputable medical journal, by
the late Dr. ATW Simeons, a British born Physician, graduated in Germany
and residing in Rome (Italy),
back as far as 1954.
Soon after the publication of this information, many healthcare
professionals rushed to Dr Simeons¹ Clinic to learn the protocol at first
hand. Dr. Simeons received an unmanageable number of requests, a situation
that finally forced him to write a book: Pounds and Inches: A new approach
to obesity, which was privately published.
For years after, the so-called
"Fat-Clinics" mushroomed everywhere. Unfortunately, the basic
protocol was (in some cases) greatly modified, altering the dietary
composition, the hCG administration schedule and the dosage. Under these
circumstances, results obtained were not as expected.
Simultaneously, a series of double-blind studies were published. Some
of them concluded that weight loss with or without hCG was equal, that hCG
had no effect on fat mobilization, appetite or sense of hunger, or on body
fat distribution. However, another series of Investigations demonstrated
that hCG administration effectively decreased body weight more than a
placebo and that patients felt in excellent mood throughout the treatment
The controversy was finally terminated by an FDA regulation which,
based on some of the unfavorable but questionable studies, forced
pharmaceutical firms to state in hCG documentation that hCG should not be
used to treat obesity, because it was not more effective than a placebo.
Although inhibited by this limitation, the hCG protocol for weight loss
continued to be applied by quite a few MD who, ignoring the FDA verdict,
continued to apply the method in their daily practice.
hCG is a glycoproteic substance, which we believe should not be called
a hormone, since it does not fulfils the concept of a hormone's basic
The term "hormone" means in Greek "I act through
distance". It was coined in 1921 to describe a series of substances
which are secreted from an organ, or gland, and exert their actions
beyond the producing organ
For example: insulin fulfils the concept of a hormone, because it is
secreted by the pancreas, and exerts its action everywhere in the organism.
The concept is equally valid for estrogens, progesterone, thyroid
hormones, adrenal hormones.
The term hCG stands for Human Chorionic Gonadotropin. The term Human
implies that hCG should be differentiated from other Chorionic
Gonadotropin substances, since others had already been identified, e.g. a
Rat Chorionic Gonadotropin, and a Monkey Chorionic Gonadotropin. The word
Chorionic was added to its identification because when it was discovered
by Ascheim and Zondek in the urine of pregnant women, it was observed that
it was secreted by the chorion of the placenta (part of the anatomic
structure). The term Gonadotropin was assigned because when the substance
was injected into young female experimental animals, it provoked the
maturation of oocytes, causing ovulation. hCG also accelerated the
maturation of testicles in male experimental animals, but never beyond
Subsequent Investigations demonstrated that the term hCG can be quite
misleading: hCG is not only produced by the placenta, but also by nearly
human tissues, male or female, pregnant or not. Plants and bacteria also synthesize
It is unfortunate that hCG is almost solely known for its use in
obesity or infertility, as it is one of the few substances of natural origin still
remaining in the Pharmacopoeia, showing its effectiveness in several
- The hCG method for obesity treatment
As originally proposed by Dr. ATW Simeons, the method consisted of the
daily administration (by intramuscular injection) of 125 IU of hCG plus a
specific and quite detailed Very Low Hypocaloric Diet ( furnishing
approximately 500 Kcal./day.
According to Dr. Simeons, patients lost about 1 pound daily, modified
their body contour, and felt in excellent spirits throughout the treatment
Dr. Simeons postulated four basic conclusions from his method.
1. Patients under hCG lost the same amount of weight as dieting
individuals (without the medication), but under hCG fat loss was mainly
accomplished at the expense of fat and not lean mass (Dr. Belluscio
recently corroborated this finding. See:
2. hCG-treated subjects felt in excellent spirits throughout the
treatment (Dr. Belluscio recently corroborated this finding. See:
3. Diet composition was of the utmost importance: Dr. Simeons insisted
that any deviation from the standard protocol might render unfavourable
4. As a consequence of this specific fat mass mobilization, body contour
showed a tendency to modelate (change body configuration). (Dr.Belluscio
recently corroborated this finding. See:
- Biases, prejudices, interests?
We still do not know what is at stake regarding the subject of hCG and
obesity. Also, it causes concerns to us that well-trained and reputable healthcare professionals
may sustain that hCG can cause cancer, hirsutism, water retention and allergic
reactions. But still more amazing is the fact that pharmaceutical firms
must include in their hCG information leaflets that hCG has to be held
accountable for all these side effects.
If hCG is indeed responsible for all those side-effects, pregnancy
should be considered a high-risk condition, since hCG is produced in
enormous amounts during pregnancy (up to 1,000,000 IU daily). The logical
conclusion is that many pregnant women should become hirsute, develop
cancer, or be seriously edematized.
hCG is a safe substance. When used properly, and in the amounts
indicated, it has no side effects and provides no unfavorable results.
The vast majority of reported complications are related to the
simultaneous overuse of hCG and hMG (Human Menopausal Gonadotropin) to
provoke superovulation in infertility cases.
- What do treated patients have to say?
More important than our clinical
impressions, let us see what treated
patients have to say:
What can we do to help others?
ISAUC is a not-for-profit Organization, aimed at the creation of a
climate of opinion which will stir up interest, facilitate research
projects and share experiences on the hCG method throughout the world.
Patients and Healthcare Professionals are welcome to participate.
- What can, I as a patient who has been treated with the hCG in the
Help to spread this information to your friends,
neighbors and whoever
you consider might be interested, and stimulate the interest to participate as
volunteers in Research studies .
- What if I never have been treated with the hCG method in the past?
We encourage you to request any information through our Web address, or
Email. We are at your complete disposal to respond to any inquiry on the
Aou could also register to
attend future meetings and studies.
- What if I am a Healthcare Professional?
You could register at our Database, explaining your field of interest,
specialty and location. Once registered you will be given the option to
participate as a Researcher in ongoing studies, or we could assist you to
organize your own Investigation Protocol. You could also attend
our training courses.
Many thanks for your interest and cooperation
Dr. Daniel Belluscio
The International Society for Alternative Uses of human Choriogonadotropin (ISAUC)